candel-sibs

Siblings Help Advance CANDLE Syndrome Research

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Illustration of the spinal bones.

When Your Back Hurts, Don’t Let Back Pain Knock You Flat

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Excessive UV exposure is a major risk factor for skin cancer. (stock image)

Halting Inflammation After Joint Injury May Reduce Risk of Osteoarthritis Later

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Red staining in this cell represents the presence of a newly discovered thyroid hormone receptor p30 TRα1 in signaling “hubs” areas where signaling molecules congregate in the cell membrane. Credit: Renate Pilz M.D. University of California San Diego.

Newly Discovered Thyroid Hormone Receptor Helps Control Bone Formation Advance Offers Novel Strategy for Treating Osteoporosis

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Excessive UV exposure is a major risk factor for skin cancer. (stock image)

Chronic UV Exposure Induces Opioid Response That is Associated with Tanning Addiction

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Audrey Lapidus and her son Calvin who was diagnosed with a rare genetic disorder after months of inconclusive tests stumped doctors.

Clinical Exome Sequencing Detects Disease-Causing Glitches

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A Stat3 inhibitor improved muscle repair in mice. The results suggest a potential approach to treating muscle-wasting diseases in people.

Controlling Muscle Repair

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NIAMS Summer 2014 Interns.

NIAMS Interns Reflect on Their 2014 Summer Experience

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Shutterstock: hands resting on armrest.

Antibodies Act Jointly to Promote Inflammation in Rheumatoid Arthritis

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Vertebra from a mouse engineered to have osteogenesis imperfecta (upper panel). Following eight weeks of treatment with an antibody that blocks TGF-β activity the bone mass returned to normal levels (lower panel). Credit: Brendan Lee M.D. Ph.D. Baylor College of Medicine.

Study in Mice Links Key Signaling Molecule to Underlying Cause of Osteogenesis Imperfecta

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Blood vessels (yellow) of children with SAVI become inflamed and damaged indicated here in red.

Gene Linked to Rare Inflammatory Disease in Children

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Skeletons from birth to 1 month of age are shown for mice engineered to have PSACH (on right) compared to control mice. By 28 days mice with PSACH were 12 percent shorter. Image courtesy of Karen Posey Ph.D. University of Texas Medical School at Houston.

Insights Into Severe Form of Dwarfism Could Lead to New Treatment Strategies

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hand with Rhuematoid Arthritis

Rheumatoid Arthritis When Your Immune System Attacks Your Body

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Illustration of a family under a shaded canopy at the beach.

Sun and Skin, The Dark Side of Sun Exposure

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X-ray of a hip replacement.

Commonly Prescribed Blood Thinner Associated with Higher Risk of Post-Surgery Complications

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Investigating the Causes of Chronic Itch: New Advances Could Bring Relief

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Exercise Brings Bone Benefits that Last

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International Team Identifies Biomarker for Scleroderma

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X-ray image of a child’s forearm fracture. Photo credit: eORIF LLC.

Childhood Forearm Breaks Resulting from Mild Trauma May Indicate Bone Deficits

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Left: Maternal osteocalcin crosses the placenta during pregnancy before the fetus can produce its own. Right: Osteocalcin can cross the blood-brain barrier and increases levels of certain neurotransmitters. Photo credit: Gerard Karsenty M.D. Ph.D. Columbia University

Bone Hormone Found to Influence Brain Development and Function in Mice

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Illustration of a tick being grasped by tweezers and lifted from the skin’s surface.

Tick Talk, Block Tick Bites and Lyme Disease

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Dr. Mariana Kaplan

Progress Made in Lupus Diagnosis and Treatment

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A baseball pitcher throwing with cross-sections underneath of bigger bone under the throwing arm and smaller bone under the non-throwing arm.

Physical Activity Brings Lasting Bone Benefits

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ACL injuries and meniscal tears are common among young athletes. (shutterstock image).

Long-term Follow-up Data From Large Orthopaedic Studies May Help Guide Clinical Practice

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The most common symptoms of Sjögren’s syndrome are dry eyes and mouth but the disease can affect other tissues and organs as well. Credit: Sjögren’s Syndrome Foundation.

New Genetic Susceptibility Factors for Sjögren’s Syndrome Revealed

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Epidermolysis bullosa occurs when genetic defects result in the skin’s two main layers not adhering properly at the dermal-epidermal junction.

Protein Replacement Therapy Shows Promise in Treating Rare Skin Disorder

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NIAMS scientists have found evidence that elevated numbers of osteoclasts a type of cell that degrades bone may contribute to bone loss in people with spondyloarthritis. Osteoclasts like the one shown here in the center contain multiple nuclei (clear circles) because they are formed by fusion of precursor cells. Credit: Robert A. Colbert M.D. Ph.D. NIAMS.

Bone Loss in Spondyloarthritis Linked to Protein’s Misfolding

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Mouse toe tips can regenerate within five weeks of being clipped (left) unless the Wnt signaling pathway is inactivated (right).

Fingernails Yield Clues to Limb Regeneration

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The tendon-to-bone insertion point is biomechanically compositionally and structurally complex. Photo credit: Stavros Thomopolous Ph.D. Department of Orthopaedics Washington University.

Muscle Activity Necessary for Healthy Tendon-Bone Interface Development

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